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KMID : 0359920060250050871
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Korean Journal of Nephrology
2006 Volume.25 No. 5 p.871 ~ p.876
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A Case of Diffuse Large B-cell Lymphoma in a Kidney Transplant Recipient
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Byun Seung-Woon
Park Hye-Won
Song Ju-Hyung
Oh Ji-Seon
Kim Eun-Hee
Suh Chul-Won
Park Su-Kil
Huh Joo-Ryung
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Abstract
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Posttransplant lymphoproliferative disorders (PTLD) is an infrequent but serious complication of transplantation. Previous studies have suggested the terms of reference, “early PTLD” (referring to PTLD that occurs within 1 year of transplantation) and “late PTLD” (PTLD that occurs after 1 year). Early PTLD generally involves a single organ or nodal region and often responds favorably to a decrease in immunosuppression. Late PTLD tends to be disseminated, responds less frequently to a decrease in immunosuppression, and has a dismal prognosis. We encountered a diffuse large B-cell lymphoma in a 44-year-old man who underwent kidney transplantation over 10 years ago, in 1995. In situ hybridization for Epstein-Barr virus showed positive results in tumor cell. With decreased immunosuppressants and chemotheraphy, he is currently in complete remission. Korean J Nephrol 2006;25(5):871-876)
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KEYWORD
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Posttransplant Lymphoproliferative disorders, PTLD, EBV, Epstein-Barr virus, Immunosuppression, Kidney transplantation
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